Andrea Carmine Belin

Andrea Carmine Belin

Senior Forskare | Docent
Telefon: +46852487051
Besöksadress: Solnavägen 9, 17165 Solna
Postadress: C4 Neurovetenskap, C4 Forskning Carmine Belin, 171 77 Stockholm
Del av:

Forskningsbeskrivning

  • Syftet med vår forskning är att öka förståelsen av patofysiologin bakom
    neurologiska sjukdomar med fokus på huvudvärk, främst Hortons
    huvudvärk/klusterhuvudvärk, genom att identifiera, karakterisera och
    modellera genetiska markörer inom det mänskliga genomet.

Artiklar

  • Article: CURRENT OPINION IN NEUROLOGY. 2026;39(3):326-331
    Ran C; Spulber S; Belin AC
  • Article: NPJ PARKINSONS DISEASE. 2026;12(1):127
    Vincze K; Szwajda A; Ploner A; Karlsson R; Kang X; Tang B; Qin C; Domenighetti C; Sugier P-E; Ashok Kumar Sreelatha A; Schulte C; Portugal B; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlander AB; Burbulla LF; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Toft M; Pihlstrom L; Correia Guedes L; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Ran C; Belin AC; Puschmann A; Clarke CE; Morrison KE; Tan M; Krainc D; Farrer MJ; Landoulsi Z; Kruger R; Gasser T; Elbaz A; Sharma M; Pedersen NL; Carlsson S; Hagg S; Wirdefeldt K
  • Article: NPJ PARKINSONS DISEASE. 2026;12(1):160
    Landoulsi Z; Sreelatha AAK; Kuznetsov N; Schulte C; Bobbili DR; Montanucci L; Leu C; Niestroj L-M; Hassanin E; Domenighetti C; Sugier P-E; Radivojkov-Blagojevic M; Lichtner P; Portugal B; Edsall C; Kruger J; Hernandez DG; Blauwendraat C; Mellick GD; Zimprich A; Pirker W; Tan M; Rogaeva E; Lang A; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlander AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Burbulla LF; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Pavelka L; Kolber P; van de Warrenburg BPC; Bloem BR; Singleton AB; Vitale D; Toft M; Pihlstrom L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Clarke CE; Morrison KE; Krainc D; Farrer MJ; Lal D; Elbaz A; Gasser T; Kruger R; Sharma M; May P
  • Article: CEPHALALGIA. 2026;46(4):3331024261440136
    Sanches CD; Spulber S; Olofsgard FJ; Fourier C; Sundholm A; Lantz M; Sjostrand C; Waldenlind E; Steinberg A; Houlden H; Matharu M; Ran C; Belin AC
  • Article: BRAIN. 2026;149(1):290-301
    Danelakis A; Kumelj T; Winsvold BS; Bjørk MH; Nachev P; Matharu M; Giles D; Tronvik E; Langseth H; Stubberud A; International Headache Genetics Consortium
  • Article: HEADACHE. 2025;65(8):1294-1307
    Jennysdotter Olofsgard F; Ran C; Spulber S; Steinberg A; Sjostrand C; Waldenlind E; Lantz M; Sundholm A; Soderstrom M; Dahlgren A; Belin AC
  • Article: NEUROLOGY. 2024;103(3):e209620
    Domenighetti C; Sugier P-E; Ashok Kumar Sreelatha A; Schulte C; Grover S; Portugal B; Lee P-C; May P; Bobbili D; Radivojkov Blagojevic M; Lichtner P; Singleton AB; Hernandez D; Edsall C; Mellick GD; Zimprich AA; Pirker W; Rogaeva EA; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlander AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli AL; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; Van De Warrenburg BPC; Bloem BR; Toft M; Pihlstrm L; Correia Guedes L; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Tan MM; Krainc D; Burbulla LF; Farrer M; Kruger R; Gasser T; Sharma M; Elbaz A
  • Article: JOURNAL OF HEADACHE AND PAIN. 2024;25(1):121
    Ran C; Olofsgard FJ; Wellfelt K; Steinberg A; Belin AC
  • Journal article: LANCET NEUROLOGY. 2024;23(7):712-724
    Petersen AS; Lund N; Goadsby PJ; Belin AC; Wang S-J; Fronczek R; Burish M; Cho S-J; Peres MFP; Jensen RH
  • Article: SCIENTIFIC REPORTS. 2024;14(1):12094
    Qu K; Li M-X; Yu P; Wu B-H; Shi M; Dong M
  • Article: JOURNAL OF HEADACHE AND PAIN. 2024;25(1):85
    Edvinsson JCA; Ran C; Olofsgard FJ; Steinberg A; Edvinsson L; Belin AC
  • Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2024;74(2):45
    Olofsgard FJ; Ran C; Qin Y; Fourier C; Waldenlind E; Steinberg A; Sjostrand C; Belin AC
  • Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1376698
    Li G; Duan S; Zheng T; Zhu T; Qu B; Liu L; Liu Z
  • Article: BRAIN SCIENCES. 2024;14(4):348
    Smedfors G; Olofsgard FJ; Steinberg A; Waldenlind E; Ran C; Belin AC
  • Article: PLOS ONE. 2023;18(10):e0292180
    Vollstedt E-J; Madoev H; Aasly A; Ahmad-Annuar A; Al-Mubarak B; Alcalay RN; Alvarez V; Amorin I; Annesi G; Arkadir D; Bardien S; Barker RA; Barkhuizen M; Basak AN; Bonifati V; Boon A; Brighina L; Brockmann K; Belin AC; Carr J; Clarimon J; Cornejo-Olivas M; Guedes LC; Corvol J-C; Crosiers D; Damasio J; Das P; de Carvalho Aguiar P; De Rosa A; Dorszewska J; Ertan S; Ferese R; Ferreira J; Gatto E; Genc G; Giladi N; Gomez-Garre P; Hanagasi H; Hattori N; Hentati F; Hoffman-Zacharska D; Illarioshkin SN; Jankovic J; Jesus S; Kaasinen V; Kievit A; Klivenyi P; Kostic V; Koziorowski D; Kuehn AA; Lang AE; Lim S-Y; Lin C-H; Lohmann K; Markovic V; Martikainen MH; Mellick G; Merello M; Milanowski L; Mir P; Oztop-Cakmak O; Pimentel MMG; Pulkes T; Puschmann A; Rogaeva E; Sammler EM; Skaalum Petersen M; Skorvanek M; Spitz M; Suchowersky O; Tan AH; Termsarasab P; Thaler A; Tumas V; Valente EM; van de Warrenburg B; Williams-Gray CH; Wu R-M; Zhang B; Zimprich A; Solle J; Padmanabhan S; Klein C
  • Article: JOURNAL OF HEADACHE AND PAIN. 2023;24(1):121
    Lund NLT; Petersen AS; Fronczek R; Tfelt-Hansen J; Belin AC; Meisingset T; Tronvik E; Steinberg A; Gaul C; Jensen RH
  • Article: JOURNAL OF HEADACHE AND PAIN. 2023;24(1):114
    Ran C; Olofsgard FJ; Steinberg A; Sjoestrand C; Waldenlind E; Dahlgren A; Belin AC
  • Article: ANNALS OF NEUROLOGY. 2023;94(4):713-726
    Winsvold B; Harder AVEA; Ran C; Chalmer M; Dalmasso MC; Ferkingstad E; Tripathi KP; Bacchelli E; Borte S; Fourier CS; Petersen AH; Vijfhuizen L; Magnusson S; O'Connor E; Bjornsdottir G; Happola P; Wang Y-F; Callesen I; Kelderman T; Gallardo VJ; de Boer I; Olofsgard FJ; Heinze K; Lund N; Thomas LF; Hsu C-L; Pirinen M; Hautakangas H; Ribases M; Guerzoni S; Sivakumar P; Yip J; Heinze A; Kucukali FB; Ostrowski SS; Pedersen OE; Kristoffersen ES; Martinsen AE; Artigas MS; Lagrata S; Cainazzo MM; Adebimpe J; Quinn O; Goebel CE; Cirkel A; Volk A; Heilmann-Heimbach SE; Skogholt AH; Gabrielsen ME; Wilbrink LA; Danno D; Mehta DR; Guobjartsson DF; Rosendaal FR; van Dijk KW; Fronczek RA; Wagner M; Scherer M; Goebel HA; Sleegers K; Sveinsson O; Pani L; Zoli M; Ramos-Quiroga JA; Dardiotis E; Steinberg A; Riedel-Heller S; Sjostrand C; Thorgeirsson TE; Stefansson H; Southgate L; Trembath RC; Vandrovcova J; Noordam R; Paemeleire KH; Stefansson K; Fann CS-J; Waldenlind E; Tronvik E; Jensen RH; Chen S-P; Houlden H; Terwindt GC; Kubisch C; Maestrini E; Vikelis M; Pozo-Rosich P; Belin AC; Matharu M; van den Maagdenberg AMJM; Hansen TF; Ramirez A; Zwart J-A
  • Article: HUMAN GENETICS. 2023;142(8):1185-1200
    Zhang W; Zhang L; Yang LM; Xiao C; Wu X; Yan P; Cui H; Yang C; Zhu J; Wu X; Tang MR; Wang Y; Chen L; Liu YA; Zou YM; Zhang LE; Yang C; Yao Y; Li J; Liu ZS; Zhang B; Jiang X
  • Article: MOVEMENT DISORDERS. 2023;38(4):604-615
    Sugier P-E; Lucotte EA; Domenighetti C; Law MH; Iles MM; Brown K; Amos C; McKay JD; Hung RJ; Karimi M; Bacq-Daian D; Boland-Auge A; Olaso R; Deleuze J-F; Lesueur F; Ostroumova E; Kesminiene A; de Vathaire F; Guenel P; Sreelatha AAK; Schulte C; Grover S; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlaender AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrom L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen N; Ran C; Belin AC; Puschmann A; Roedstroem EY; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Kruger R; Gasser T; Sharma M; Truong T; Elbaz A
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Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 januari 2026 - 31 december 2029
    Cluster headache (CH) is a severe disabling condition which strikes as an excruciating unilateral pain and there is no cure. It is more common among men, but more severe among women and sleep deficiencies have been reported. Genetics, circadian rhythm and inflammation have been implicated in CH pathophysiology. The overall purpose of this research project is to understand the molecular mechanisms and clinical characteristics of CH in order improve diagnosis and treatment by identifying biomarkers and novel drug targets, as well as develop future treatment strategies. This will be achieved by the following specific aims: 1) Characterize candidate genes coupled to CH pathophysiology2) Explore sleep and circadian rhythm in relation to CH and treatment3) Validate sex hormones with regard to CH characteristics4) Identify inflammatory mechanisms involved in CH5) Develop and characterize cell models of CH pathophysiologyThese aims will be achieved by using a worldleading CH biobank comprising biological tissue and clinical and demographic data. The research team has a unique position to execute the proposed project during a five-year period due to its complementary multidisciplinary expertise, in key areas such as genetics, cell biology, bioinformatics, circadian rhythm and neurology. These studies will allow insight into the pathophysiological mechanisms and aid the identification of biomarkers and disease-associated pathways suitable to target in the development of novel drugs.
  • Hospital@Home: Person-centered Digital Transformation for Integrated Home Care. Work-package 6 Migraine Care (Karolinska is lead) and WP 7 Cluster Headache Care.
    Innovative Health Initiative Joint Undertaking (delegated by the European Commission)
    1 januari 2026 - 30 juni 2029
    Ett stort samverkans forskningsprojekt för att möta nya utmaningar inom hälso- och sjukvården genom innovation, samarbete över gränser och integrering av tekniska lösningar. Initiativet Hospital@Home (H@H) syftar till att bryta ett ensidigt silo-tänkande genom att fokusera på flera sjukdomstillstånd som innebär hög sjuklighet och ofta kräver intensiv övervakning och koordinerad vård. De valda sjukdomsområdena omfattar kardiovaskulära sjukdomar, pulmonologi, minor stroke/TIA, migrän och Hortons huvudvärk, eftersom dessa bedöms ha stor potential att förbättras genom tidig upptäckt av sjukdomsprogression eller försämring med hjälp av avancerade övervakningsverktyg. Den totala finansieringen för H@H var 21,8 miljoner euro.
  • Kartläggning av klusterhuvudvärk med fokus på ärftlighet, kön, sömn och dygnsrytm för effektivare diagnos och behandling
    ALF Medicin 2026 projektmedel
    1 januari 2026 - 31 december 2028
  • Mapping of the mechanisms behind cluster headache with a focus on inflammation
    Hjärnfonden
    1 juli 2023 - 31 december 2025
  • In depth characterization of genetic markers behind primary headache disorders with a focus on cluster headache
    Hjärnfonden
    1 juli 2022 - 31 december 2024
  • Deciphering the mechanisms behind primary headache disorders with focus on genetics and circadian rhythm
    Karolinska Institutet
    1 januari 2021 - 31 december 2024
  • Validering av läkemedelsrespons vid Hortons huvudvärk kopplat till genetik och dygnsrytm.
    Region Stockholm
    1 januari 2021 - 31 december 2023
  • Genetic screening of Cluster headache in relation to treatment and circadian rhythm
    Hjärnfonden
    1 juli 2020 - 31 december 2022
  • Swedish Research Council
    1 januari 2018 - 31 december 2020
  • Swedish Research Council
    1 januari 2013 - 31 december 2015

Anställningar

  • Senior Forskare, Neurovetenskap, Karolinska Institutet, 2022-

Examina och utbildning

  • Docent, Neurovetenskap, Karolinska Institutet, 2011
  • MEDICINE DOKTORSEXAMEN, Neurovetenskap, On Parkinson’s Disease and Schizophrenia: Case Control Studies, Cellular Localization and Modelling of Candidate Genes, Institutionen för neurovetenskap, Karolinska Institutet, 2003
  • Medicine Magisterexamen, Karolinska Institutet, 1999

Uppdrag

Priser och utmärkelser

  • Cluster Headache Award, Headache Science and Neurorehabilitation Unit, University of Pavia, 2024
  • Svenska Migränsällskapets stipendium, Swedish Headache Society, 2014
  • Top-Cited Paper Award, Top-cited paper award for “Parkinson's disease: a genetic perspective“ published in the FEBS Journal Volume 275, issue 7, 2008., Federation of European Biochemical Societies, 2008
  • Special grant for younger scientists, Awarded with the special grants available for young scientists, establishing their own research projects., Karolinska Institutet, 2008
  • Postdoc-stipend, Hjärnfonden, 2005

Handledning

Uppdrag i kommitté

Utvärdering av avhandlingsarbete

Redaktör för vetenskaplig tidskrift

Sakkunniggranskning för vetenskaplig tidskrift

  • Movement Disorders
  • Brain Research
  • Journal of Neurology
  • Environment International
  • Neuroscience Letters
  • Microarrays, MDPI
  • Genetics Research
  • The Journal of Biomedical Science
  • Scientific Reports
  • Neuropsychiatric Disease and Treatment
  • BioMed research international
  • Journal of Pain Research
  • Neurotoxicology
  • EBioMedicine
  • Cephalalgia Reports
  • PLOS ONE
  • The Journal of Headache and Pain
  • JAMA Neurology
  • Expert Opinion On Pharmacotherapy
  • Frontiers in Neurology
  • Cephalalgia
  • Headache
  • Neurology
  • Current Medical Research & Opinion
  • Brain Sciences

Expert

  • Granskare av större forskningsansökningar i lokal konkurrens, Karolinska Institutet Research Funds, Karolinska Institutet, 2022-2024
  • Granskare av större forskningsansökningar i lokal konkurrens, Grant reviewer of KID-applications, KID funding is a block grant for partial financing of doctoral education at KI., Karolinska Institutet, 2021-2022

Konferenser och events

  • Moderator, International Headache Congress, Update on trigeminal autonomic cephalalgias, 2023
  • Inbjuden föredragshållare, International Headache Congress, Recent developments in the genetics of cluster headache, 2023
  • Moderator, International Headache Congress, Headache Trainees Excellence Tournament, 2023
  • Inbjuden föredragshållare, European Headache Congress, Genetics in migraine, 2023
  • Inbjuden föredragshållare, Lundbeck R&D oragnization – Idea Forum, Cluster Headache – The alarm clock of pain, 2023
  • Inbjuden föredragshållare, Regional Headache Conference, The genetics of cluster headache, 2022
  • Inbjuden föredragshållare, Nordic Migraine Symposium, Biomarkers - with focus on genetics, 2022
  • Inbjuden föredragshållare, Framtidens migränvård - danska och svenska lärdomar, Hur bli världsledande inom klusterhuvudvärk och genetikforskning, 2022
  • Muntlig presentation av inskickat abstract, International Headache Congress, Circadian rhythm gene expression in cluster headache, 2019
  • Moderator, Nordic Neuroscience Meeting, Cluster headache and migraine genetics - new insights, 2019
  • Muntlig presentation av inskickat abstract, Migraine Trust International Symposium, Involvement of CGRP receptor RAMP1 in cluster headache – A Swedish case-control study, 2018
  • Poster-presentation av inskickat abstract, International Headache Congress, Cluster Headache – Clinical pattern and a new severity scale in a Swedish cohort, 2017

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