Lars Farde

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2026;46(6):1730-1738
Quantification of pituitary 5-HT_1B receptors with positron emission tomography: Negligible specific binding despite conspicuous uptake
Garde M; Varnas K; Lundberg J; Svensson J; Farde L; Matheson GJ; Tiger M
Article: MOLECULAR IMAGING AND BIOLOGY. 2026;28(2):290-297
The Binding of the High Affinity Radioligand Fallypride to the D2-dopamine Receptor is Sensitive to Injected Mass - a PET Study in Rodents
Toth M; Tari L; Nag S; Qiu T; Jia Z; Haggkvist J; Mukherjee J; Varrone A; Halldin C; Farde L
Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2025;150:109382
Radiolabeling and preclinical evaluation of [18F]AZ14193052, a novel CNS penetrant and subtype-selective fluorinated PET radioligand for PARP1
Hognasbacka A; Dahl K; Johnstrom P; Gonzalez MAC; Cselenyi Z; Jucaite A; Pike A; Johannes J; Cosulich S; Lawrence R; Stenkrona P; Farde L; Halldin C; Varrone A; Schou M
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2025;392(9):103638
Brain exposure of the mesenchymal-epithelial transition inhibitor savolitinib in nonhuman primates: A positron emission tomography study
Johnstrom P; Cselenyi Z; Miah K; Jucaite A; Scarfe G; Gonzalez MAC; Farde L; Halldin C; Vishwanathan K; Schou M
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2025;45(8):1606-1616
In vivo quantification of [¹¹C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase
Bolin M; Nag S; Arakawa R; Varrone A; Farde L; Martarello L; Kaliszczak MA; Halldin C; Moren AF
Journal article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2025;8(7):1986-1995
Radiosynthesis and Evaluation of ¹¹C-Labeled Imidazolyl Pyrimidine Derivatives for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3
Li Y; Dahl K; Elmore CS; Sandell J; Takano A; Halldin C; Farde L; Ahlgren C; Cochrane A; Rong J; Chen J; Zhao C; Zhou X; Patel JS; Song Z; Chaudhary A; Gao Y; Sun Z; Zhang Z; Feng S; Haider A; Liang SH; Schou M
Article: IMAGING NEUROSCIENCE. 2025;3:imag_a_00464
Putative mapping of α-subunits in the human brain: A PET study of GABA_A receptor binding
Cselenyi Z; Jucaite A; Farde L
Article: PHARMACEUTICALS. 2025;18(2):135
Radiolabeling and Preliminary In Vivo Evaluation of the Candidate CCR2 Targeting PET Radioligand [¹¹C]AZD2423
Dahl K; Johnstrom P; Toth M; Bolin M; Varnas K; Nakao R; Takano A; Khani Meynaq Y; Bayrakdarian M; Cselenyi Z; Halldin C; Farde L; Schou M
Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2024;7(8):2414-2423
Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2
Li Y; Dahl K; Johnstrom P; Varnas K; Farde L; Halldin C; Medd A; Maier D; Powell ME; Chen J; Van R; Patel J; Chaudhary A; Gao Y; Song Z; Haider A; Shao Y; Elmore CS; Liang S; Schou M
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2024;27(5):pyae021
Altered Serotonin 1B Receptor Binding After Escitalopram for Depression Is Correlated With Treatment Effect
Garde M; Matheson GJ; Varnaes K; Svenningsson P; Hedman-Lagerloef E; Lundberg J; Farde L; Tiger M
Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;98(4):1391-1401
High Contrast PET Imaging of Subcortical and Allocortical Amyloid-β in Early Alzheimer's Disease Using [¹¹C]AZD2184
Mattsson P; Cselenyi Z; Moren AF; Freund-Levi Y; Wahlund L-O; Halldin C; Farde L
Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108465
O-69 Discovery, preclinical validation and early human imaging with [11C]AZ14193391 – the first blood-brain barrier permeable and subtype selective PARP1 PET radioligand
Gonzalez MAC; Jucaite A; Cselenyi Z; Johnstrom P; Pike A; Högnäsbacka A; Dahl K; Balazs A; Degorce S; Ghosh A; Hande S; Johannes J; Staniewska A; Leo E; Hammerlik P; Davies B; Cosulich S; Swales J; Lawrence R; Stenkrona P; Farde L; Halldin C; Schou M
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(17):3206-3211
PET Evaluation of the Novel F-18 Labeled Reversible Radioligand [¹⁸F]GEH200449 for Detection of Monoamine Oxidase-B in the Non-Human Primate Brain
Varnas K; Nag S; Halldin C; Farde L
Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40
CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance
Orhan F; Goiny M; Becklen M; Mathe L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
Article: SYNAPSE-STRUCTURE FUNCTION CONNECTIVITY. 2023;77(4):e22269
[¹¹C]PBB3 binding in Aβ(-) or Aβ(+) corticobasal syndrome
Cselenyi Z; Wallin J; Tjerkoski J; Bloth B; Svensson S; Nennesmo I; Sunnemark D; Jelic V; Farde L; Svenningsson P
Article: CTS-CLINICAL AND TRANSLATIONAL SCIENCE. 2023;16(6):955-965
Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non-small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study
Ekman S; Cselenyi Z; Varrone A; Jucaite A; Martin H; Schou M; Johnstrom P; Laus G; Lewensohn R; Brown AP; van der Aart J; Vishwanathan K; Farde L
Article: ADDICTION. 2023;118(6):1053-1061
Striatal dopamine D2 receptor availability as a predictor of subsequent alcohol use in social drinkers
Jangard S; Jayaram-Lindstrom N; Isacsson NH; Matheson GJ; Plaven-Sigray P; Franck J; Borg J; Farde L; Cervenka S
Article: FRONTIERS IN NUCLEAR MEDICINE. 2023;2:1080005
Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans
Cselenyi Z; Jucaite A; Ewing P; Stenkrona P; Kristensson C; Johnstrom P; Schou M; Bolin M; Halldin C; Larsson B; Grime K; Eriksson UG; Farde L
Journal article: NEUROSCIENCE APPLIED. 2023;2:101035
Glutamate 5 receptor availability differences in twins discordant for autism and controls, do shared genetics matter
Griffioen G; Andersson M; Tangen Ä; Bolin M; Farde L; Halldin C; Bölte S; Lundberg J; Borg J
Article: ACS CHEMICAL NEUROSCIENCE. 2022;13(14):2078-2083
Synthesis and Preclinical Evaluation of [¹¹C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor
Dahl K; Johnstrom P; Forsberg-Moren A; Gustafsson B; Miranda-Azpiazu P; Khani Y; Halldin C; Farde L; Elmore CS; Schou M
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Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2025;28:i35-i36
NO DIFFERENCES IN SYNAPTIC DENSITY IN TWINS WITH AUTISM AND THEIR NON-AUTISTIC CO-TWINS. HOWEVER, ARE DIFFERENCES IN SV2A BINDING POTENTIAL IN AUTISTIC BRAINS A MATTER OF WHITE MATTER?
Griffioen-Jarfalk G; Bolin M; Stephanov V; Cervenka S; Castelo-Branco M; Martins R; Lundberg J; Mehra C; Howes O; Murphy D; Bolte S; Farde L; Borg J
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2024;65
Evaluation of 3H/11C-labeled mGluR2 modulators based on isoindolone scaffold
Li Y; Dahl K; Johnstrom P; Varnas K; Halldin C; Farde L; Chen J; Yuan H; Haider A; Schou M; Liang S
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023;50(SUPPL 1):S257
In vivo quantification of [¹¹C]BIO-1819578, a novel radioligand for O-GlcNAcase, in non-human primates using Positron Emission Tomography
Bolin M; Nag S; Datta P; Arakawa R; Meynaq YK; Lin E; Genung N; Hering H; Guckian K; Martarello L; Kaliszczak M; Farde L; Stenkrona P; Halldin C; Moren AF
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023;50(SUPPL 1):S254
First imaging of PARP1 in the living human brain - a translational PET study with [¹¹C]AZ3391
Schou M; Pike A; Jucaite A; Johnstrom P; Gonzalez MC; Hognasbacka A; Dahl K; Ghosh A; Johannes J; Staniszewska A; Leo E; Hamerlik P; Davies B; Cosulich S; Swales J; Lawrence R; Squatrito M; Mueller N; Sousa V; Bartek J; Stragliotto G; Stenkrona P; Farde L; Halldin C; Cselenyi Z
Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S55
Discovery, preclinical validation and early human imaging with [¹¹C]AZ14193391-the first blood-brain barrier permeable and subtype selective PARP1 PET radioligand
Gonzalez MAC; Jucaite A; Cselenyi Z; Johnstrom P; Pike A; Hognasbacka A; Dahl K; Balazs A; Degorce S; Ghosh A; Hande S; Johannes J; Staniewska A; Leo E; Hammerlik P; Davies B; Cosulich S; Swales J; Lawrence R; Stenkrona P; Farde L; Halldin C; Schou M
Preprint: RESEARCH SQUARE. 2022
Lung muscarinic receptor occupancy by tiotropium: translational Positron Emission Tomography studies in non-human primates and humans
Cselényi Z; Jucaite A; Ewing P; Stenkrona P; Kristensson C; Johnström P; Schou M; Bolin M; Halldin C; Larsson B; Grime K; Eriksson UG; Farde L
Letter: MOVEMENT DISORDERS. 2022;37(8):1776-1778
Glia Imaging Shows Clinical Utility in Differentiating Parkinson's Disease from Multiple System Atrophy
Rinne JO; Jucaite A; Cselenyi Z; Farde L
Preprint: RESEARCH SQUARE. 2022
Lung muscarinic receptor occupancy by tiotropium: translational PET studies in non-human primates and humans
Cselényi Z; Jucaite A; Ewing P; Stenkrona P; Kristensson C; Johnström P; Schou M; Bolin M; Halldin C; Larsson B; Grime K; Eriksson UG; Farde L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):169-170
Centrum semiovale as reference region - An evaluation of methods to quantify [18F]FPEB PET binding data in man
Andersson M; Varnas K; Halldin C; Borg J; Farde L; Lundberg J
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):260-261
Lower thalamic dopamine D2-receptor binding and connectivity in drug-naive patients with psychosis - A combined [11C]FLB 457 PET and DTI study
Victorsson P; Plaven-Sigray P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Agartz I; Halldin C; Farde L; Cervenka S
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):258-260
Validation of kinfitr: An open-source tool for reproducible PET kinetic modelling
Tjerkaski J; Cervenka S; Farde L; Matheson GJ
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2021;16(3):S620
A PET and MRI Study Exploring Osimertinib Brain Exposure and Efficacy in EGFRm NSCLC CNS Metastases
Ekman S; Cselenyi Z; Varrone A; Jucaite A; Martin H; Schou M; Johnstrom P; Laus G; Lewensohn R; Brown A; Van der Aart J; Vishwanathan K; Farde L
Book chapter: PET AND SPECT IN PSYCHIATRY. 2021;p. 3-15
Neuroimaging in Psychiatric Drug Development and Radioligand Development for New Targets
Takano A; Halldin C; Farde L
Preprint: SSRN ELECTRONIC JOURNAL. 2021
Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Pet Study Using [ ¹¹C ] PBR28 and Machine Learning Enhanced Analysis
Jucaite A; Cselényi Z; Kreisl WC; Rabiner EA; Varrone A; Carson RE; Rinne JO; Savage A; Schou M; Johnström P; Svenningsson P; Rascol O; Meissner WG; Barone P; Seppi K; Kaufmann H; Wenning GK; Poewe W; Farde L
Preprint: BIORXIV. 2020
Low convergent validity of [ ₁₁ C]raclopride binding in extrastriatal brain regions: a PET study of within-subject correlations with [ ₁₁ C]FLB 457
Freiburghaus T; Svensson J; Matheson G; Plavén-Sigray P; Lundberg J; Farde L; Cervenka S
Conference publication: SCHIZOPHRENIA BULLETIN. 2020;46:S135-S136
LOWER THALAMIC DOPAMINE D2-RECEPTOR BINDING IN DRUG-NAIVE PATIENTS WITH PSYCHOSIS - A REPLICATION STUDY USING POSITRON EMISSION TOMOGRAPHY
Victorsson P; Plaven-Sigray P; Matheson G; Santillo A; Lee M; Collste K; Fatouros-Bergman H; Agartz I; Halldin C; Farde L; Cervenka S
Preprint: BIORXIV. 2020
Kinfitr – an open source tool for reproducible PET modelling: validation and evaluation of test-retest reliability
Tjerkaski J; Cervenka S; Farde L; Matheson GJ
Letter: NEUROIMAGE. 2020;207:116371
In response to the letter "[¹¹C]raclopride and extrastriatal binding to D2/3 receptors"
Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Book chapter: NEUROIMAGING IN SCHIZOPHRENIA. 2020;p. 145-159
Molecular Imaging
Cervenka S; Farde L
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2019;14(10):S842
An Open-Label PET-MRI Study to Determine Brain Exposure of Osimertinib in Patients with EGFR Mutant NSCLC and CNS Metastases
Ekman S; Varrone A; Jucaite A; Vishwanathan K; Brown A; Cselenyi Z; Martin H; Lewensohn R; Schou M; Laus G; Van Der Aart J; Johnstrom P; Singh N; Farde L
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Forskningsbidrag

MRI brain morphology and connectivity in schizophrenia; translational studies of four cohorts; importance of genetic and non-genetic risk factors for brain development and clinical outcome
Swedish Research Council
1 januari 2018 - 31 december 2020
Longterm brain dysfunction after surgery and trauma
Swedish Research Council
1 januari 2017 - 31 december 2020
PET-study of the time course for dopaminergic degeneration in Parkinson´s disease
Swedish Research Council
1 januari 2017 - 31 december 2019
PET studies of the glutamate system in schizophrenia
Swedish Research Council
1 januari 2016 - 31 december 2019
Respiratory control and cognitive function in anesthesia and surgery
Swedish Research Council
1 januari 2014 - 31 december 2016
PET studies of brain biomarkers in schizophrenia
Swedish Research Council
1 januari 2012 - 31 december 2015
Brain immune activation in schizophrenia - functional investigations of a novel antipsychotic drug target
Swedish Research Council
1 januari 2012 - 31 december 2013
PET studies of neurotransmission systems in major psychiatric disorders
Swedish Research Council
1 januari 2009 - 31 december 2011
PET ANALYSIS OF DOPAMINE D2 RECEPTORS IN SCHIZOPHRENIA
National Institute of Mental Health
1 maj 1986 - 31 augusti 2000

Anställningar

Professor Emeritus, Klinisk neurovetenskap, Karolinska Institutet, 2025-2027
Professor, Klinisk neurovetenskap, Karolinska Institutet, 2021-2024
Professor/Överläkare, Klinisk neurovetenskap, Karolinska Institutet, 1999-2021
Professor, Bitr/Överläkare, Klinisk neurovetenskap, Karolinska Institutet, 1996-1998

Examina och utbildning

Docent, Allmän psykiatri, Karolinska Institutet, 1989

Artiklar

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Nyheter från KI

Kalenderhändelser från KI