Kamila Czene
Professor
E-postadress: kamila.czene@ki.se
Telefon: +46852486144
Besöksadress: Nobels väg 12a, 17165 Solna
Postadress: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Czene, 171 77 Stockholm
Om mig
- Jag är professor i cancerepidemiologi vid Institutionen för medicinsk epidemiologi och biostatistik. Min forskning fokuserar på bröstcanceretiologi i en vid bemärkelse. Läs mer om min forskning på min engelska profilsida.
Utvalda publikationer
- Article: JAMA ONCOLOGY. 2024;10(3):372-379Rodriguez J; Grassmann F; Xiao Q; Eriksson M; Mao X; Bajalica-Lagercrantz S; Hall P; Czene K
- Article: JAMA ONCOLOGY. 2024;10(1):63-70Mao X; He W; Humphreys K; Eriksson M; Holowko N; Yang H; Tapia J; Hall P; Czene K
- Article: ANNALS OF ONCOLOGY. 2021;32(10):1286-1293He W; Eriksson M; Eliasson E; Grassmann F; Backlund M; Gabrielson M; Hammarstrom M; Margolin S; Thoren L; Wengstrom Y; Borgquist S; Hall P; Czene K
- Article: EUROPEAN HEART JOURNAL. 2021;42(34):3361-3370Grassmann F; Yang H; Eriksson M; Azam S; Hall P; Czene K
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(6):548-557He W; Grassmann F; Eriksson M; Eliasson E; Margolin S; Thoren L; Hall P; Czene K
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(3):251-258Holm J; Li J; Darabi H; Eklund M; Eriksson M; Humphreys K; Hall P; Czene K
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(20):2262-2269He W; Fang F; Varnum C; Eriksson M; Hall P; Czene K
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(9):1030-1037Holm J; Humphreys K; Li J; Ploner A; Cheddad A; Eriksson M; Törnberg S; Hall P; Czene K
- Article: ANNALS OF ONCOLOGY. 2015;26(3):517-522Li J; Holm J; Bergh J; Eriksson M; Darabi H; Lindström LS; Törnberg S; Hall P; Czene K
- Article: ANNALS OF ONCOLOGY. 2014;25(10):1966-1972Lindstrom LS; Li J; Lee M; Einbeigi Z; Hartman M; Hall P; Czene K
Artiklar
- Article: EBIOMEDICINE. 2026;129:106352Rodriguez J; Grassmann F; Kaukonen D; Humphreys K; Eriksson M; Zhang Y; Morawitz K; Gabrielson M; Hall P; Czene K
- Article: CELL. 2026;189(11):3339-3357.e11Koprulu M; Smith-Byrne K; Ferolito BR; Macdonald-Dunlop E; Luan J; Hedman AK; Ogamba CF; Kuliesius J; Repetto L; Ramisch A; Abbasi F; Arnlov J; Assimes TL; Bjorck HM; Bjorkander S; Bottcher M; Butterworth AS; Chen Z; Cho K; Clarke RJ; Cox SR; Czene K; Danesh J; Dedoussis G; Elmstahl S; Eriksson N; Eriksson P; Esko T; Ferreiro-Iglesias A; Franks PW; Fu J; Gaziano JM; Ghanbari M; Gieger C; Gilly A; Grallert H; Gunter MJ; Gustafsson S; Goteson A; Hall PFL; Hansson O; Harris SE; Hayward C; Herder C; Hernandez-Pacheco N; Hijazi Z; Hillary RF; Hopewell JC; Hu S; Hwang S-J; Jern C; Johansson A; Jonsson L; Kalnapenkis A; Kerrison ND; Kho PF; Klaric L; Kohleick L; Kraft J; Landen M; Levy D; Li L; Lind L; Long J; Mattsson-Carlgren N; Melen E; Merid SK; Mertins P; Michaelsson K; Moller PL; Murgia F; Nyegaard M; Park Y-C; Pearson E; Peters J; Petrie JR; Png G; Polasek O; Prins BP; Ripke S; Roden M; Rohde PD; Said S; Shen X; Schwenk JM; Siegbahn A; Smith JG; Stanne TM; Suhre K; Sundstrom J; Thorand B; Valdes-Marquez E; Vallerga CL; van Meurs JBJ; Vinuela A; Vosa U; Wallentin L; Walters RG; Wareham NJ; Weber JE; Weersma RK; Wilson JF; Winther S; Yasmeen S; Zanetti D; Zeggini E; Zhao JH; Zhernakova A; Zhernakova DV; Ziehm M; Kessler BM; Pereira AC; Malarstig A; Pietzner M; Langenberg C
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2026;18(850):eady7414Eriksson M; Czene K; Scott C; Stoddard S; Smith H; Hall P; Vachon C
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2026;195(5):1231-1241Suger AH; Chen H; Haas CB; Fan S; Scott CG; Bolla MK; Dennis J; Dunning AM; Michailidou K; Wang Q; Fasching PA; Haeberle L; Stone J; Gago-Dominguez M; Castelao JE; Murphy RA; Aronson K; Couch FJ; Yadav S; Milne RL; Hopper JL; Norman A; Eliassen AH; Tapper WJ; Eccles DM; Evans DG; Astley S; Hall P; Czene K; Pharoah PDP; Antoniou AC; Garcia-Closas M; Berrington A; Easton DF; Gierach GL; Tamimi RM; Vachon CM; Lindstrom S; Harrison TA
- Journal article: THE LANCET OBSTETRICS GYNAECOLOGY & WOMEN'S HEALTH. 2026;2(5):e451-e459Zhang X; Eriksson M; Mavaddat N; Dennis J; Astley SM; Gabrielson M; Giles GG; Hart SN; Hunter DJ; Le Marchand L; Lush M; Michailidou K; Scott CG; Tamimi RM; Wang Q; Howell SJ; Naven M; Antoniou AC; Aronson KJ; Bolla MK; Castelao JE; Couch FJ; Czene K; Dunning AM; Eliassen AH; Evans DG; Gago-Dominguez M; García-Closas M; Haiman CA; Milne RL; Pharoah PDP; Southey MC; Stone J; Murphy RA; de Gonzalez AB; Vachon CM; Hall P; Easton DF
- Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2026;:djag087Hall P; Hammarstrom M; Bergqvist J; Czene K; Eriksson M; Gabrielson M; Tapia J; Quay S; Nash S; Backlund M
- Article: CANCER CAUSES & CONTROL. 2026;37(5):72Klintman M; Rosendahl AH; Johannesen BR; Cronin-Fenton D; Eriksson M; Czene K; Hall P; Borgquist S
- Article: STATISTICS IN MEDICINE. 2026;45(8-9):e70504Orsini L; Gasparini A; Czene K; Humphreys K
- Article: INTERNATIONAL JOURNAL OF CANCER. 2026;158(5):1184-1192Kaukonen D; Ploner A; Zeng E; Bergqvist J; Czene K
- Article: BREAST. 2026;85:104619Billaud A; Figlioli G; Mooser C; Casamassima I; Azzoni V; Srivatsa J; Colombo M; Caleca L; Ahearn TU; Andrulis IL; Antoniou AC; Beckmann MW; Behrens S; Bermisheva M; Bogdanova NV; Bolla MK; Bonanni B; Bruning T; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chang-Claude J; Czene K; Dennis J; Devilee P; Dork T; Dunning AM; Eriksson M; Evans DG; Fasching PA; Figueroa JD; Gabrielson M; Gago-Dominguez M; Gonzalez-Neira A; Guenel P; Hadjisavvas A; Hahnen E; Hamann U; Hillemanns P; Hollestelle A; Hooning MJ; Hoppe R; Howell A; Jakubowska A; Kristensen VN; Lubinski J; Lush M; Manoukian S; Mavroudis D; Milne RL; Mulligan AM; Newman WG; Obi N; Panayiotidis MI; Pita G; Rashid MU; Rhenius V; Saloustros E; Sawyer EJ; Schmutzler RK; Shah M; Southey MC; Spurdle AB; Tomlinson I; Truong T; Wang Q; Wendt C; Auer PL; Boddicker NJ; Bodelon C; Burnside ES; Chen F; Couch FJ; Domchek SM; Eliassen HA; Haiman C; Hodge JM; Hu C; Huang H; Lindstrom S; Martinez ME; Nathanson KL; Neuhausen SL; O'brien KM; Olson JE; Palmer JR; Patel AV; Ruddy KJ; Sandler DP; Teras LR; Weinberg CR; Weitzel JN; Winham SJ; Yadav S; Yao S; Zirpoli G; Janatova M; Kleibl Z; Kleiblova P; Soukupova J; Zhao Q; Devereux L; James PA; Campbell IG; Nguyen-Dumont T; Dowty JG; Andrieu N; Lesueur F; Stoppa-Lyonnet D; de la Hoya M; Radice P; Sorensen CS; Peterlongo P
- Article: JCO PRECISION ONCOLOGY. 2026;10:e2500852White BL; Ficorella L; Yang X; Czene K; Eriksson M; Hall P; Archer S; Tischkowitz M; Usher-Smith JA; Easton DF; Antoniou AC
- Article: CANCERS. 2025;17(21):3561Ho PJ; Loo CKY; Lim RJY; Goh MH; Abubakar M; Ahearn TU; Andrulis IL; Antonenkova NN; Aronson KJ; Augustinsson A; Behrens S; Bodelon C; Bogdanova NV; Bolla MK; Brantley KD; Brenner H; Byers H; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chanock SJ; Chenevix-Trench G; Choi J-Y; Colonna SV; Czene K; Daly MB; Derouane F; Dork T; Eliassen AH; Engel C; Eriksson M; Evans DG; Fletcher O; Fritschi L; Gago-Dominguez M; Genkinger JM; Geurts-Giele WRR; Glendon G; Hall P; Hamann U; Ho CYS; Ho W-K; Hooning MJ; Hoppe R; Howell A; Humphreys K; Ito H; Iwasaki M; Jakubowska A; Jernstrom H; John EM; Johnson N; Kang D; Kim S-W; Kitahara CM; Ko Y-D; Kraft P; Kwong A; Lambrechts D; Larsson S; Li S; Lindblom A; Linet M; Lissowska J; Lophatananon A; MacInnis RJ; Mannermaa A; Manoukian S; Margolin S; Matsuo K; Michailidou K; Milne RL; Mohd Taib NA; Muir KR; Murphy RA; Newman WG; O'brien KM; Obi N; Olopade OI; Panayiotidis MI; Park SK; Park-Simon T-W; Patel AV; Peterlongo P; Plaseska-Karanfilska D; Pylkas K; Rashid MU; Rennert G; Rodriguez J; Saloustros E; Sandler DP; Sawyer EJ; Scott CG; Shahi S; Shu X-O; Shulman K; Simard J; Southey MC; Stone J; Taylor JA; Teo S-H; Teras LR; Terry MB; Torres D; Vachon CM; Houdt MV; Verhoeven J; Weinberg CR; Wolk A; Yamaji T; Yip CH; Zheng W; Hartman M; Li J
- Article: BRITISH JOURNAL OF CANCER. 2025;133(6):844-855Ficorella L; Yang X; Mavaddat N; Carver T; Hassan H; Dennis J; Tyrer J; Ho W-K; Teo S-H; Hartman M; Li J; Eriksson M; Czene K; Hall P; Rahman T; Bacon A; Hardy S; Stokes AE; Donoso FS; Archer S; Simard J; Pharoah PDP; Usher-Smith JA; Tischkowitz M; Easton DF; Antoniou AC
- Article: JAMA NETWORK OPEN. 2025;8(10):e2535330Mao X; He W; Tapia J; Holowko N; Bergqvist J; Humphreys K; Czene K
- Article: BMJ-BRITISH MEDICAL JOURNAL. 2025;390:e085029Ma Z; He W; Zhang Y; Mao X; Tapia J; Hall P; Humphreys K; Czene K
- Article: JCO PRECISION ONCOLOGY. 2025;9:e2500203Ficorella L; Eriksson M; Czene K; Leslie G; Yang X; Carver T; Stokes AE; Easton DF; Hall P; Antoniou AC
- Article: BJC REPORTS. 2025;3(1):47Vesterlund G; Mao X; Gissler M; Abedi-Valugerdi M; Skoog T; Heinonen S; Sparen P; Pettersson K; Kere J; Czene K; Wedenoja S
- Article: JAMA NETWORK OPEN. 2025;8(7):e2519236Le Cornet C; Jung AY; Behrens S; Middha P; Truong T; Jernstrom H; Bolla MK; Wang Q; Southey MC; Freeman LEB; Koutros S; Stone J; Rennert G; Shulman K; Aronson KJ; Murphy RA; Guenel P; Patel AV; Bodelon C; Teras LR; Shahi S; Lacey JV; Dossus L; Kaaks R; Holleczek B; Brenner H; Brauch H; Hoppe R; Czene K; Hall PFL; Mannermaa A; Wu AH; Obi N; Michailidou K; Panayiotidis MI; McLean C; Haiman CA; Augustinsson A; Zheng W; Shu X-O; Perou CM; Troester MA; Van Alsten S; Eliassen AH; Abubakar M; Kraft P; Ahearn TU; Evans DG; Wolk A; Milne RL; Easton DF; Pharoah PDP; Schmidt MK; Garcia-Closas M; Vachon CM; Fortner RT; Chang-Claude J
- Journal article: CLINICAL CANCER RESEARCH. 2025;31(12_Supplement):ps16-05-ps16-05Hall P; Nash S; Bäcklund M; Bergqvist J; Hammarström M; Eriksson M; Quay S; Czene K
- Article: NATURE COMMUNICATIONS. 2025;16(1):4852Zanti M; O'Mahony DG; Parsons MT; Dorling L; Dennis J; Boddicker NJ; Chen W; Hu C; Naven M; Yiangou K; Ahearn TU; Ambrosone CB; Andrulis IL; Antoniou AC; Auer PL; Baynes C; Bodelon C; Bogdanova N; Bojesen SE; Bolla MK; Brantley KD; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chang-Claude J; Chen F; Chenevix-Trench G; Conroy DM; Czene K; De Nicolo A; Domchek SM; Doerk T; Dunning AM; Eliassen AH; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gago-Dominguez M; Garcia-Closas M; Glendon G; Gonzalez-Neira A; Grassmann F; Hadjisavvas A; Haiman CA; Hamann U; Hart SN; Hartman MBA; Ho W-K; Hodge JM; Hoppe R; Howell SJ; Jakubowska A; Khusnutdinova EK; Ko Y-D; Kraft P; Kristensen VN; Lacey JV; Li J; Lim GH; Lindstrom S; Lophatananon A; Luccarini C; Mannermaa A; Martinez ME; Mavroudis D; Milne RL; Muir K; Nathanson KL; Nunez-Torres R; Obi N; Olson JE; Palmer JR; Panayiotidis MI; Patel AV; Pharoah PDP; Polley EC; Rashid MU; Ruddy KJ; Saloustros E; Sawyer EJ; Schmidt MK; Southey MC; Tan VK-M; Teo SH; Teras LR; Torres D; Trentham-Dietz A; Truong T; Vachon CM; Wang Q; Weitzel JN; Yadav S; Yao S; Zirpoli GR; Cline MS; Devilee P; Tavtigian SV; Goldgar DE; Couch FJ; Easton DF; Spurdle AB; Michailidou K
- Visa fler
Alla övriga publikationer
- Conference publication: 2026;:a11.1-a1a11White B; Ficorella L; Yang X; Eriksson M; Czene K; Hall P; Tischkowitz M; Usher-Smith J; Easton D; Antoniou A
- Corrigendum: NATURE COMMUNICATIONS. 2025;16(1):8237Lawrenson K; Kar S; McCue K; Kuchenbaeker K; Michailidou K; Tyrer J; Beesley J; Ramus SJ; Li Q; Delgado MK; Lee JM; Aittomaki K; Andrulis IL; Anton-Culver H; Arndt V; Arun BK; Arver B; Bandera EV; Barile M; Barkardottir RB; Barrowdale D; Beckmann MW; Benitez J; Berchuck A; Bisogna M; Bjorge L; Blomqvist C; Blot W; Bogdanova N; Bojesen A; Bojesen SE; Bolla MK; Bonanni B; Borresen-Dale A-L; Brauch H; Brennan P; Brenner H; Bruinsma F; Brunet J; Buhari SA; Burwinkel B; Butzow R; Buys SS; Cai Q; Caldes T; Campbell I; Cannioto R; Chang-Claude J; Chiquette J; Choi J-Y; Claes KBM; Collonge-Rame M-A; Damette A; Barouk-Simonet E; Bonnet F; Bubien V; Sevenet N; Longy M; Vaur D; Berthet P; Castera L; Ferrer SF; Bignon Y-J; Uhrhammer N; Coron F; Faivre L; Baurand A; Jacquot C; Bertolone G; Lizard S; Leroux D; Dreyfus H; Rebischung C; Peysselon M; Peyrat J-P; Fournier J; Revillion F; Adenis C; Venat-Bouvet L; Leone M; Boutry-Kryza N; Calender A; Giraud S; Verny-Pierre C; Lasset C; Bonadona V; Barjhoux L; Sobol H; Bourdon V; Noguchi T; Remenieras A; Coupier I; Pujol P; Sokolowska J; Bronner M; Delnatte C; Bezieau S; Mari V; Gauthier-Villars M; Buecher B; Rouleau E; Golmard L; Moncoutier V; Belotti M; de Pauw A; Elan C; Fourme E; Birot A-M; Saule C; Laurent M; Houdayer C; Lesueur F; Mebirouk N; Coulet F; Colas C; Soubrier F; Warcoin M; Prieur F; Lebrun M; Kientz C; Muller D; Fricker J-P; Toulas C; Guimbaud R; Gladieff L; Feillel V; Mortemousque I; Bressac-de-Paillerets B; Caron O; Guillaud-Bataille M; Cook LS; Cox A; Cramer DW; Cross SS; Cybulski C; Czene K; Daly MB; Damiola F; Dansonka-Mieszkowska A; Darabi H; Dennis J; Devilee P; Diez O; Doherty JA; Domchek SM; Dorfling CM; Dork T; Dumont M; Ehrencrona H; Ejlertsen B; Ellis S; Gregory H; Miedzybrodzka Z; Morrison PJ; Donaldson A; Rogers MT; Kennedy MJ; Porteous ME; Brady A; Barwell J; Foo C; Lalloo F; Side LE; Eason J; Henderson A; Walker L; Cook J; Snape K; Murray A; Mccann E; Engel C; Lee E; Evans DG; Fasching PA; Feliubadalo L; Figueroa J; Flesch-Janys D; Fletcher O; Flyger H; Foretova L; Fostira F; Foulkes WD; Fridley BL; Friedman E; Frost D; Gambino G; Ganz PA; Garber J; Garcia-Closas M; Gentry-Maharaj A; Ghoussaini M; Giles GG; Glasspool R; Godwin AK; Goldberg MS; Goldgar DE; Gonzalez-Neira A; Goode EL; Goodman MT; Greene MH; Gronwald J; Guenel P; Haiman CA; Hall P; Hallberg E; Hamann U; Hansen TVO; Harrington PA; Hartman M; Hassan N; Healey S; Rookus MA; van Leeuwen FE; van der Kolk LE; Schmidt MK; Russell NS; de Lange JL; Wijnands R; Collee JM; Hooning MJ; Seynaeve C; van Deurzen CHM; Obdeijn IM; van Asperen CJ; Tollenaar RAEM; van Cronenburg TCTEF; Kets CM; Ausems MGEM; van der Pol CC; van Os TAM; Waisfisz Q; Meijers-Heijboer HEJ; Gomez-Garcia EB; Oosterwijk JC; Mourits MJ; de Bock GH; Vasen HF; Siesling S; Verloop J; Overbeek LIH; Heitz F; Herzog J; Hogdall E; Hogdall CK; Hogervorst FBL; Hollestelle A; Hopper JL; Hulick PJ; Huzarski T; Imyanitov EN; Fox S; Kirk J; Lindeman G; Price M; Bowtell D; Defazio A; Webb P; Isaacs C; Ito H; Jakubowska A; Janavicius R; Jensen A; John EM; Johnson N; Kabisch M; Kang D; Kapuscinski M; Karlan BY; Khan S; Kiemeney LA; Kjaer SK; Knight JA; Konstantopoulou I; Kosma V-M; Kristensen V; Kupryjanczyk J; Kwong A; de la Hoya M; Laitman Y; Lambrechts D; Le N; De Leeneer K; Lester J; Levine DA; Li J; Lindblom A; Long J; Lophatananon A; Loud JT; Lu K; Lubinski J; Mannermaa A; Manoukian S; Le Marchand L; Margolin S; Marme F; Massuger LFAG; Matsuo K; Mazoyer S; Mcguffog L; McLean C; McNeish I; Meindl A; Menon U; Mensenkamp AR; Milne RL; Montagna M; Moysich KB; Muir K; Mulligan AM; Nathanson KL; Ness RB; Neuhausen SL; Nevanlinna H; Nord S; Nussbaum RL; Odunsi K; Offit K; Olah E; Olopade OI; Olson JE; Olswold C; O'Malley D; Orlow I; Orr N; Osorio A; Park SK; Pearce CL; Pejovic T; Peterlongo P; Pfeiler G; Phelan CM; Poole EM; Pylkas K; Radice P; Rantala J; Rashid MU; Rennert G; Rhenius V; Rhiem K; Risch HA; Rodriguez G; Rossing MA; Rudolph A; Salvesen HB; Sangrajrang S; Sawyer EJ; Schildkraut JM; Schmidt MK; Schmutzler RK; Sellers TA; Seynaeve C; Shah M; Shen C-Y; Shu X-O; Sieh W; Singer CF; Sinilnikova OM; Slager S; Song H; Soucy P; Southey MC; Stenmark-Askmalm M; Stoppa-Lyonnet D; Sutter C; Swerdlow A; Tchatchou S; Teixeira MR; Teo SH; Terry KL; Terry MB; Thomassen M; Tibiletti MG; Tihomirova L; Tognazzo S; Toland AE; Tomlinson I; Torres D; Truong T; Tseng C-C; Tung N; Tworoger SS; Vachon C; van den Ouweland AMW; van Doorn HC; van Rensburg EJ; Van't Veer LJ; Vanderstichele A; Vergote I; Vijai J; Wang Q; Wang-Gohrke S; Weitzel JN; Wentzensen N; Whittemore AS; Wildiers H; Winqvist R; Wu AH; Yannoukakos D; Yoon S-Y; Yu J-C; Zheng W; Zheng Y; Khanna KK; Simard J; Monteiro AN; French JD; Couch FJ; Freedman ML; Easton DF; Dunning AM; Pharoah PD; Edwards SL; Chenevix-Trench G; Antoniou AC; Gayther SA
- Preprint: 2025Vinattieri MV; Bonetti M; Czene K
- Conference publication: BREAST CANCER RESEARCH AND TREATMENT. 2025;211(1):S26-S27Eriksson M; Czene K; Conant EC; Hall P
- Preprint: MEDRXIV. 2025Zhang X; Eriksson M; Mavaddat N; Dennis J; Astley SM; Gabrielson M; Giles GG; Hart SN; Hunter DJ; Le Marchand L; Lush M; Michailidou K; Scott CG; Wang Q; Howell SJ; Naven M; Antoniou AC; Aronson KJ; Bolla MK; Castelao JE; Couch FJ; Czene K; Dunning AM; Evans DG; Gago-Dominguez M; García-Closas M; Haiman CA; Milne RL; Pharoah PDP; Southey MC; Stone J; Murphy RA; de Gonzalez AB; Vachon CM; Hall P; Easton DF
- Preprint: MEDRXIV. 2025;MEDRXIVHo PJ; Loo CKY; Goh MH; Abubakar M; Ahearn TU; Andrulis IL; Antonenkova NN; Aronson KJ; Augustinsson A; Behrens S; Bodelon C; Bogdanova NV; Bolla MK; Brantley K; Brenner H; Byers H; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chanock SJ; Chenevix-Trench G; Choi J-Y; Colonna SV; Czene K; Daly MB; Derouane F; Dörk T; Eliassen AH; Engel C; Eriksson M; Evans DG; Fletcher O; Fritschi L; Gago-Dominguez M; Genkinger JM; Geurts-Giele WRR; Glendon G; Hall P; Hamann U; Ho CYS; Ho W-K; Hooning MJ; Hoppe R; Howell A; Humphreys K; ABCTB Investigators; kConFab Investigators; SGBCC Investigators; MyBrCa Investigators; Ito H; Iwasaki M; Jakubowska A; Jernström H; John EM; Johnson N; Kang D; Kim S-W; Kitahara CM; Ko Y-D; Kraft P; Kwong A; Lambrechts D; Larsson S; Li S; Lindblom A; Linet M; Lissowska J; Lophatananon A; MacInnis RJ; Mannermaa A; Manoukian S; Margolin S; Matsuo K; Michailidou K; Milne RL; Taib NAM; Muir K; Murphy RA; Newman WG; O'Brien KM; Obi N; Olopade OI; Panayiotidis MI; Park SK; Park-Simon T-W; Patel AV; Peterlongo P; Plaseska-Karanfilska D; Pylkäs K; Rashid MU; Rennert G; Rodriguez J; Saloustros E; Sandler DP; Sawyer EJ; Scott CG; Shahi S; Shu X-O; Shulman K; Simard J; Southey MC; Stone J; Taylor JA; Teo S-H; Teras LR; Terry MB; Torres D; Vachon CM; Van Houdt M; Verhoeven J; Weinberg CR; Wolk A; Yamaji T; Yip CH; Zheng W; Hartman M; Li J
- Preprint: MEDRXIV. 2025Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK populationFicorella L; Yang X; Mavaddat N; Carver T; Hassan H; Dennis J; Tyrer J; Ho W-K; Teo S-H; Hartman M; Li J; Eriksson M; Czene K; Hall P; Rahman T; Bacon A; Hardy S; Stokes AE; Donoso FS; Archer S; Simard J; Pharoah PDP; Usher-Smith JA; Tischkowitz M; Easton DF; Antoniou AC
- Preprint: MEDRXIV. 2025Ficorella L; Eriksson M; Czene K; Leslie G; Yang X; Carver T; Stokes AE; Easton DF; Hall P; Antoniou AC
- Preprint: MEDRXIV. 2024;MEDRXIVZanti M; O'Mahony DG; Parsons MT; Dorling L; Dennis J; Boddicker NJ; Chen W; Hu C; Naven M; Yiangou K; Ahearn TU; Ambrosone CB; Andrulis IL; Antoniou AC; Auer PL; Baynes C; Bodelon C; Bogdanova NV; Bojesen SE; Bolla MK; Brantley KD; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chang-Claude J; Chen F; Chenevix-Trench G; NBCS Collaborators; Conroy DM; Czene K; De Nicolo A; Domchek SM; Dörk T; Dunning AM; Eliassen AH; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gago-Dominguez M; García-Closas M; Glendon G; González-Neira A; Grassmann F; Hadjisavvas A; Haiman CA; Hamann U; Hart SN; Hartman MBA; Ho W-K; Hodge JM; Hoppe R; Howell SJ; kConFab Investigators; Jakubowska A; Khusnutdinova EK; Ko Y-D; Kraft P; Kristensen VN; Lacey JV; Li J; Lim GH; Lindström S; Lophatananon A; Luccarini C; Mannermaa A; Martinez ME; Mavroudis D; Milne RL; Muir K; Nathanson KL; Nuñez-Torres R; Obi N; Olson JE; Palmer JR; Panayiotidis MI; Patel AV; Pharoah PDP; Polley EC; Rashid MU; Ruddy KJ; Saloustros E; Sawyer EJ; Schmidt MK; Southey MC; Tan VK-M; Teo SH; Teras LR; Torres D; Trentham-Dietz A; Truong T; Vachon CM; Wang Q; Weitzel JN; Yadav S; Yao S; Zirpoli GR; Cline MS; Devilee P; Tavtigian SV; Goldgar DE; Couch FJ; Easton DF; Spurdle AB; Michailidou K
- Corrigendum: NATURE GENETICS. 2024;56(8):1763-1764Kentistou KA; Kaisinger LR; Stankovic S; Vaudel M; de Oliveira EM; Messina A; Walters RG; Liu X; Busch AS; Helgason H; Thompson DJ; Santoni F; Petricek KM; Zouaghi Y; Huang-Doran I; Gudbjartsson DF; Bratland E; Lin K; Gardner EJ; Zhao Y; Jia RY; Terao C; Riggan MJ; Bolla MK; Yazdanpanah M; Yazdanpanah N; Bradfield JP; Broer L; Campbell A; Chasman DI; Cousminer DL; Franceschini N; Franke LH; Girotto G; He C; Jarvelin M-R; Joshi PK; Kamatani Y; Karlsson R; Luan J; Lunetta KL; Maegi R; Mangino M; Medland SE; Meisinger C; Noordam R; Nutile T; Concas MP; Polasek O; Porcu E; Ring SM; Sala C; Smith AV; Tanaka T; van der Most PJ; Vitart V; Wang CA; Willemsen G; Zygmunt M; Ahearn TU; Andrulis IL; Anton-Culver H; Antoniou AC; Auer PL; Barnes CLK; Beckmann MW; de Gonzalez AB; Bogdanova NV; Bojesen SE; Brenner H; Buring JE; Canzian F; Chang-Claude J; Couch FJ; Cox A; Crisponi L; Czene K; Daly MB; Demerath EW; Dennis J; Devilee P; De Vivo I; Dork T; Dunning AM; Dwek M; Eriksson JG; Fasching PA; Fernandez-Rhodes L; Ferreli L; Fletcher O; Gago-Dominguez M; Garcia-Closas M; Garcia-Saenz JA; Gonzalez-Neira A; Grallert H; Guenel P; Haiman CA; Hall P; Hamann U; Hakonarson H; Hart RJ; Hickey M; Hooning MJ; Hoppe R; Hopper JL; Hottenga J-J; Hu FB; Huebner H; Hunter DJ; Jernstrom H; John EM; Karasik D; Khusnutdinova EK; Kristensen VN; Lacey JV; Lambrechts D; Launer LJ; Lind PA; Lindblom A; Magnusson PKE; Mannermaa A; McCarthy MI; Meitinger T; Menni C; Michailidou K; Millwood IY; Milne RL; Montgomery GW; Nevanlinna H; Nolte IM; Nyholt DR; Obi N; O'Brien KM; Offit K; Oldehinkel AJ; Ostrowski SR; Palotie A; Pedersen OB; Peters A; Pianigiani G; Plaseska-Karanfilska D; Pouta A; Pozarickij A; Radice P; Rennert G; Rosendaal FR; Ruggiero D; Saloustros E; Sandler DP; Schipf S; Schmidt CO; Schmidt MK; Small K; Spedicati B; Stampfer M; Stone J; Tamimi RM; Teras LR; Tikkanen E; Turman C; Vachon CM; Wang Q; Winqvist R; Wolk A; Zemel BS; Zheng W; van Dijk KW; Alizadeh BZ; Bandinelli S; Boerwinkle E; Boomsma DI; Ciullo M; Chenevix-Trench G; Cucca F; Esko T; Gieger C; Grant SFA; Gudnason V; Hayward C; Kolcic I; Kraft P; Lawlor DA; Martin NG; Nohr EA; Pedersen NL; Pennell CE; Ridker PM; Robino A; Snieder H; Sovio U; Spector TD; Stockl D; Sudlow C; Timpson NJ; Toniolo D; Uitterlinden A; Ulivi S; Volzke H; Wareham NJ; Widen E; Wilson JF; Pharoah PDP; Li L; Easton DF; Njolstad PR; Sulem P; Murabito JM; Murray A; Manousaki D; Juul A; Erikstrup C; Stefansson K; Horikoshi M; Chen Z; Farooqi IS; Pitteloud N; Johansson S; Day FR; Perry JRB; Ong KK
- Preprint: MEDRXIV. 2024Wilcox N; Tyrer JP; Dorling L; Dennis J; Naven M; Abubakar M; Ahearn TU; Andrulis IL; Antoniou AC; Bogdanova NV; Bojesen SE; Bolla MK; Brauch H; Camp NJ; Chang-Claude J; Czene K; Dörk T; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gardner EJ; González-Neira A; Guénel P; Hahnen E; Hall P; Hartman M; Hooning MJ; Jakubowska A; Khusnutdinova EK; Kristensen VN; Li J; Lindblom A; Lophatananon A; Mannermaa A; Manoukian S; Milne RL; Nuñez-Torres R; Obi N; Panayiotidis MI; Park SK; Perry JRB; Rashid MU; Saloustros E; Sawyer EJ; Schmidt MK; Southey MC; Spurdle AB; Torres D; Wang Q; Simard J; Teo SH; Dunning AM; Devilee P; Easton DF
- Preprint: RESEARCH SQUARE. 2024Tapia J; Gabrielson M; Hammarström M; Wengström Y; Bergqvist J; Tuuliainen A; Eriksson M; Czene K; Hall P; Bäcklund M
- Preprint: MEDRXIV. 2024;MEDRXIVYiangou K; Mavaddat N; Dennis J; Zanti M; Wang Q; Bolla MK; Abubakar M; Ahearn TU; Andrulis IL; Anton-Culver H; Antonenkova NN; Arndt V; Aronson KJ; Augustinsson A; Baten A; Behrens S; Bermisheva M; de Gonzalez AB; Białkowska K; Boddicker N; Bodelon C; Bogdanova NV; Bojesen SE; Brantley KD; Brauch H; Brenner H; Camp NJ; Canzian F; Castelao JE; Cessna MH; Chang-Claude J; Chenevix-Trench G; Chung WK; NBCS Collaborators; Colonna SV; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Devilee P; Dörk T; Dunning AM; Eccles DM; Eliassen AH; Engel C; Eriksson M; Evans DG; Fasching PA; Fletcher O; Flyger H; Fritschi L; Gago-Dominguez M; Gentry-Maharaj A; González-Neira A; Guénel P; Hahnen E; Haiman CA; Hamann U; Hartikainen JM; Ho V; Hodge J; Hollestelle A; Honisch E; Hooning MJ; Hoppe R; Hopper JL; Howell S; Howell A; ABCTB Investigators; kConFab Investigators; Jakovchevska S; Jakubowska A; Jernström H; Johnson N; Kaaks R; Khusnutdinova EK; Kitahara CM; Koutros S; Kristensen VN; Lacey JV; Lambrechts D; Lejbkowicz F; Lindblom A; Lush M; Mannermaa A; Mavroudis D; Menon U; Murphy RA; Nevanlinna H; Obi N; Offit K; Park-Simon T-W; Patel AV; Peng C; Peterlongo P; Pita G; Plaseska-Karanfilska D; Pylkäs K; Radice P; Rashid MU; Rennert G; Roberts E; Rodriguez J; Romero A; Rosenberg EH; Saloustros E; Sandler DP; Sawyer EJ; Schmutzler RK; Scott CG; Shu X-O; Southey MC; Stone J; Taylor JA; Teras LR; van de Beek I; Willett W; Winqvist R; Zheng W; Vachon CM; Schmidt MK; Hall P; MacInnis RJ; Milne RL; Pharoah PDP; Simard J; Antoniou AC; Easton DF; Michailidou K
- Preprint: MEDRXIV. 2023;MEDRXIVKentistou KA; Kaisinger LR; Stankovic S; Vaudel M; de Oliveira EM; Messina A; Walters RG; Liu X; Busch AS; Helgason H; Thompson DJ; Santon F; Petricek KM; Zouaghi Y; Huang-Doran I; Gudbjartsson DF; Bratland E; Lin K; Gardner EJ; Zhao Y; Jia R; Terao C; Riggan M; Bolla MK; Yazdanpanah M; Yazdanpanah N; Bradfield JP; Broer L; Campbell A; Chasman DI; Cousminer DL; Franceschini N; Franke LH; Girotto G; He C; Järvelin M-R; Joshi PK; Kamatani Y; Karlsson R; Luan J; Lunetta KL; Mägi R; Mangino M; Medland SE; Meisinger C; Noordam R; Nutile T; Concas MP; Polašek O; Porcu E; Ring SM; Sala C; Smith AV; Tanaka T; van der Most PJ; Vitart V; Wang CA; Willemsen G; Zygmunt M; Ahearn TU; Andrulis IL; Anton-Culver H; Antoniou AC; Auer PL; Barnes CL; Beckmann MW; Berrington A; Bogdanova NV; Bojesen SE; Brenner H; Buring JE; Canzian F; Chang-Claude J; Couch FJ; Cox A; Crisponi L; Czene K; Daly MB; Demerath EW; Dennis J; Devilee P; Vivo ID; Dörk T; Dunning AM; Dwek M; Eriksson JG; Fasching PA; Fernandez-Rhodes L; Ferreli L; Fletcher O; Gago-Dominguez M; García-Closas M; García-Sáenz JA; González-Neira A; Grallert H; Guénel P; Haiman CA; Hall P; Hamann U; Hakonarson H; Hart RJ; Hickey M; Hooning MJ; Hoppe R; Hopper JL; Hottenga J-J; Hu FB; Hübner H; Hunter DJ; ABCTB Investigators; Jernström H; John EM; Karasik D; Khusnutdinova EK; Kristensen VN; Lacey JV; Lambrechts D; Launer LJ; Lind PA; Lindblom A; Magnusson PK; Mannermaa A; McCarthy MI; Meitinger T; Menni C; Michailidou K; Millwood IY; Milne RL; Montgomery GW; Nevanlinna H; Nolte IM; Nyholt DR; Obi N; O'Brien KM; Offit K; Oldehinkel AJ; Ostrowski SR; Palotie A; Pedersen OB; Peters A; Pianigiani G; Plaseska-Karanfilska D; Pouta A; Pozarickij A; Radice P; Rennert G; Rosendaal FR; Ruggiero D; Saloustros E; Sandler DP; Schipf S; Schmidt CO; Schmidt MK; Small K; Spedicati B; Stampfer M; Stone J; Tamimi RM; Teras LR; Tikkanen E; Turman C; Vachon CM; Wang Q; Winqvist R; Wolk A; Zemel BS; Zheng W; van Dijk KW; Alizadeh BZ; Bandinelli S; Boerwinkle E; Boomsma DI; Ciullo M; Chenevix-Trench G; Cucca F; Esko T; Gieger C; Grant SF; Gudnason V; Hayward C; Kolčić I; Kraft P; Lawlor DA; Martin NG; Nøhr EA; Pedersen NL; Pennell CE; Ridker PM; Robino A; Snieder H; Sovio U; Spector TD; Stöckl D; Sudlow C; Timpson NJ; Toniolo D; Uitterlinden A; Ulivi S; Völzke H; Wareham NJ; Widen E; Wilson JF; Lifelines Cohort Study; Danish Blood Donor study; Ovarian Cancer Association Consortium; Breast Cancer Association Consortium; Biobank Japan Project; China Kadoorie Biobank Collaborative Group; Pharoah PD; Li L; Easton DF; Njølstad P; Sulem P; Murabito JM; Murray A; Manousaki D; Juul A; Erikstrup C; Stefansson K; Horikoshi M; Chen Z; Farooqi IS; Pitteloud N; Johansson S; Day FR; Perry JR; Ong KK
- Preprint: RESEARCH SQUARE. 2023Malarstig A; Grassman F; Dahl L; Dimitriou M; Mcleod D; Gabrielson M; Smith-Byrne K; Thomas C; Huang T-H; Forsberg S; Eriksson P; Ulfstedt M; Johansson M; Sokolov A; Schioth H; Hall P; Schwenk J; Czene K; Hedman A
- Preprint: RES SQ. 2023;RES SQMorra A; Schreurs MAC; Andrulis IL; Anton-Culver H; Augustinsson A; Beckmann MW; Behrens S; Bojesen SE; Bolla MK; Brauch H; Broeks A; Buys SS; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chung WK; Collaborators N; Colonna SV; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Dennis J; Devilee P; Dörk T; Dunning AM; Dwek M; Easton DF; Eccles DM; Eriksson M; Evans DG; Fasching PA; Fehm TN; Figueroa JD; Flyger H; Gabrielson M; Gago-Dominguez M; García-Closas M; García-Sáenz JA; Genkinger J; Grassmann F; Gündert M; Hahnen E; Haiman CA; Hamann U; Harrington PA; Hartikainen JM; Hoppe R; Hopper JL; Houlston RS; Howell A; Investigators A; Investigators K; Jakubowska A; Janni W; Jernström H; John EM; Johnson N; Jones ME; Kristensen VN; Kurian AW; Lambrechts D; Marchand LL; Lindblom A; Lubiński J; Lux MP; Mannermaa A; Mavroudis D; Mulligan AM; Muranen TA; Nevanlinna H; Nevelsteen I; Neven P; Newman WG; Obi N; Offit K; Olshan AF; Park-Simon T-W; Patel AV; Peterlongo P; Phillips K-A; Plaseska-Karanfilska D; Polley EC; Presneau N; Pylkäs K; Rack B; Radice P; Rashid MU; Rhenius V; Robson M; Romero A; Saloustros E; Sawyer EJ; Schmutzler RK; Schuetze S; Scott C; Shah M; Smichkoska S; Southey MC; Tapper WJ; Teras LR; Tollenaar RAEM; Tomczyk K; Tomlinson I; Troester MA; Vachon CM; van Veen EM; Wang Q; Wendt C; Wildiers H; Winqvist R; Ziogas A; Hall P; Pharoah PDP; Adank MA; Hollestelle A; Schmidt MK; Hooning MJ
- Preprint: RESEARCH SQUARE. 2022Muranen T; Morra A; Khan S; Barnes D; Bolla M; Dennis J; Keeman R; Leslie G; Parsons M; Wang Q; Ahearn T; Aittomäki K; Andrulis I; Arun B; Behrens S; Białkowska K; Bojesen S; Camp N; Chang-Claude J; Czene K; Devilee P; Domchek S; Dunning A; Engel C; Evans G; Gago-Dominguez M; Garcia-Closas M; Gerdes A-M; Glendon G; Guénel P; Hahnen E; Hamann P; Hanson H; Hooning M; Hoppe R; Izatt L; Jakubowska A; James P; Kristensen V; Lalloo F; Lindeman G; Mannermaa A; Margolin S; Neuhausen S; Newman W; Peterlongo P; Phillips K-A; Pujana MA; Rantala J; Rønlund K; Saloustros E; Schmutzler R; schneeweiss A; Singer C; Suvanto M; Tan YY; Teixeira M; Thomassen M; Tischkowitz M; Tripathi V; Wappenschmidt B; Zhao E; Easton D; Antoniou A; Chenevix-Trench G; Pharoah P; Schmidt M; Blomqvist C; Nevanlinna H
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2022;175:S95Zhang Y; Lin Y; Huang X; He W; Czene K; Yang H
- Preprint: RESEARCH SQUARE. 2022Giardiello D; Hooning M; Hauptmann M; Keeman R; Heemskerk-Gerritsen B; Becker H; Blomqvist C; Bojesen S; Bolla M; Camp N; Czene K; Devilee P; Eccles D; Fasching P; Figueroa J; Flyger H; García-Closas M; Haiman C; Hamann U; Hopper J; Jakubowska A; Leeuwen F; Lindblom A; Lubiński J; Margolin S; Martinez ME; Nevanlinna H; Nevelsteen I; Pelders S; Pharoah PDP; Siesling S; Southey M; Hout AVD; Hest LV; Chang-Claude J; Hall P; Easton D; Steyerberg E; Schmidt M
- Conference publication: ANNALS OF ONCOLOGY. 2022;33:S184Mao X; He W; Eriksson M; Lindstrom L; Holowko N; Lagercrantz SB; Humphreys K; Easton D; Hall PF; Czene K
- Visa fler
Forskningsbidrag
- Enhancing Interval Breast Cancer Detection: Integrating Molecular and Imaging Markers for Improved Screening ProtocolsFamiljen Erling-Perssons Stiftelse25 februari 2026 - 31 december 2028
- Swedish Research Council1 januari 2026 - 31 december 2029Mammography screening reduces breast cancer mortality, yet interval cancers - tumors diagnosed between screening rounds - constitute a major limitation, often presenting with aggressive phenotypes and poor prognoses. This project aims to identify epidemiological, biological, and imaging determinants of interval breast cancer to enhance risk stratification and screening efficacy. We will investigate the association between inherited genetic susceptibility, circulating biomarkers, mammographic features, and hormonal/lifestyle factors with interval cancer risk. Additionally, we will assess prognostic differences between interval and screen-detected cancers and develop an improved risk model for tailored screening strategies.The study is based on extensive Swedish population-based cohorts with linked screening, clinical, molecular, and epidemiological data. We will employ next-generation sequencing to analyze rare genetic variants, assess blood-based biomarkers for early risk detection, and apply AI-driven mammographic analysis to identify imaging features associated with interval cancers. Statistical approaches, including Cox proportional hazards models and machine learning-based risk prediction, will be utilized.Our research will provide new insights into the etiology of interval cancers and their missed detection in screening. The results will inform risk-adaptive screening strategies, ultimately improving early cancer detection and reducing mortality.
- GENETISKA OCH MAMMOGRAFISKA PREDIKTORER AV BRÖSTCANCER: FRÅN GODARTAD FÖRÄNDRING TILL METASTASERAD SJUKDOMCancerfonden1 januari 2026 - 31 december 2028
- Enhancing Interval Breast Cancer Detection: Integrating Molecular and Imaging Markers for Improved Screening Protocols.Sjöbergstiftelsen1 januari 2025 - 31 december 2027
- Enhancing Interval Breast Cancer Detection: Integrating Molecular and Imaging Markers for Improved Screening Protocols.Erling-Perssons Stiftelse1 januari 2025 - 31 december 2027
- Application of precision health concept for improvement of mammography screening for breast cancerRadiumhemmets forskningsfonder1 januari 2024
- Swedish Research Council1 januari 2024 - 31 december 2027The aim of breast cancer screening is early detection of breast cancers. Mammography screening is so far the only proven method that reduces mortality from breast cancer. Mortality from breast cancer is 20-40% lower in screened women compared to non-screened women.Among women attending the Swedish Mammography Screening Program approximately every third breast cancers is diagnosed with breast cancer in the interval between two screens, a so-called interval cancer. The interval cancers could be either masked by high mammographic density, missed at the previous screening round or fast growing and actually developing in between two screening rounds. Interval cancers are more common in women with dense breasts and are considered more aggressive than screen detected cancers.The risk of breast cancer and the possibility to detect a cancer differs profoundly between women. Women with mammographically dense breasts have an increased risk of breast cancer and the possibility to diagnose a prevalent breast is reduced due to “masking”. Women with dense breast are more likely to be diagnosed with an interval cancer then women with non-dense breasts.The aim of SMART, The Swedish Mammography Risk stratified Trial, is to test the effectiveness of individualised breast cancer screening. In short - does an individualised screening program identify cancers at an earlier, curable stage, compared to the current one-fits-all approach?
- Swedish Research Council1 januari 2024 - 31 december 2027We will develop and use novel, biologically-motivated statistical models of tumor progression to elucidate mechanisms of breast cancer progression and to predict the risk of (in particular, aggressive) breast cancer. The models will be estimated using data from Swedish and Norwegian studies which represent some of the world’s most detailed population-based studies of breast cancer and breast cancer screening, combining longitudinal register, questionnaire, image and molecular data. The models are extensions of prior methods that we have developed that separate out the roles of factors in screening and symptomatic detection of breast cancer, and tumor onset, growth and spread. The information we create is vital for planning and evaluating approaches to (secondary) prevention of breast cancer. Our risk prediction models are novel, and rigorously incorporate screening information.We will also study in detail the background of false-positive mammography results – i.e. recalls that do not lead to a diagnosis, but can be a considerable psychological burden for women. Moreover, we will use simulation-based approaches to evaluate the performance of new (personalised) screening strategies.Finally, we will use our novel statistical approaches with detailed prescription data to study the efficacy of hormone therapy in estrogen receptor-positive patients.
- Vetenskapsrådet1 januari 2023 - 31 december 2025
- IDENTIFIERING AV KVINNOR MED ÖKAD RISK FÖR DÖDLIG BRÖSTCANCERCancerfonden1 januari 2023 - 31 december 2025
- Swedish Cancer Society1 januari 2023In Sweden, four women die of breast cancer every day. The long-term goal of our research is to reduce mortality from breast cancer through early detection of the disease and through improved identification of women at high risk of dying from the disease. In order to provide a comprehensive picture of factors associated with breast cancer prognosis, we will examine, in addition to traditional tumor factors, areas that have not been studied to the same extent, such as factors of importance for prognosis, such as hereditary genetic and mammographic characteristics. In this project, we will study genetic determinants of so-called interval cancer, an aggressive and deadly subgroup of breast cancer tumors that develop between two screening occasions. We will first investigate the importance of immune-related genetic variations in the development of interval cancer. Next, we will investigate the relationship between inherited genetics, adherence to hormonal treatment and prognostic outcome. Finally, we will investigate how mammographic breast density can be used to improve diagnostics and serve as a useful indicator of early response to hormone therapy. For the development of individualized screening of women at high risk for aggressive breast cancer, it is essential to understand the role of inherited genetics. Information about hereditary genotype will be able to be used by the doctors to optimize the hormonal treatment aimed at improved prognosis. Tracking changes in mammographic density can provide clinicians with more real-time information regarding treatment outcome than a "wait-and-see" approach can. Overall, we believe our work is important to advancing research in the field and ultimately saving or extending these women's lives.
- Swedish Research Council1 januari 2021 - 31 december 2023
- Molekylära och mammografiska determinanter för bröstcancerRegion Stockholm/ALF1 januari 2021 - 1 januari 2023
- Swedish Research Council for Health Working Life and Welfare1 januari 2020 - 31 december 2023
- Cancerfonden1 januari 2020 - 31 december 2022
- Cancerfonden1 januari 2020 - 31 december 2022
- Swedish Cancer Society1 januari 2020In Sweden, a woman is diagnosed with breast cancer every hour and every six hours a woman dies from the disease. Factors that are important for the prognosis are tumor characteristics, the patient's individual characteristics, how the patient responds to treatment and any complications. In other words, there are more factors than tumor characteristics that affect the prognosis of breast cancer. In previous studies, we have found that the patient's hereditary genetic background has a significant impact on the aggressiveness of the disease. We have also shown that breast density and other mammographic factors are crucial for proper diagnosis and prognosis. The overall aim is to study genetic and mammographic factors of importance for life-threatening breast cancer. The study material is taken from population-based studies on breast cancer, with biological samples, information from questionnaires and clinical data. Our specific purposes are to identify: 1) hereditary genetic factors 2) genetic abnormalities in tumors 3) mammographic density and mammographic characteristics and analyze the relationship to prognosis. As a prognostic model for fatal breast cancer, we use interval cancers as these are aggressive and clinically interesting because they are not detected during mammography examination. In the next few years, we anticipate that we have identified even more genes that can be related to life-threatening breast cancer. In addition, we have identified prognostic markers that we have validated in the prospective KARMA study. To improve the diagnosis and prognosis of breast cancer, we see that information about breast density will be included as an obvious part of clinical practice. Our long-term goal is to develop methods for individual screening and treatment by identifying women with an increased risk of life-threatening breast cancer, which in turn will be of great importance for survival.
- Swedish Research Council for Health Working Life and Welfare1 januari 2019 - 31 december 2023
- Cancerfonden1 januari 2018 - 31 december 2019
- Visa fler
Anställningar
- Professor, Cancerepidemiologi, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2010-
- Researcher (50%), Biobanking Epidemiology, Wallenberg Foundation, Consortium North, Karolinska Institutet, 2000-2001
- Phd student, Biosciences at Novum, Karolinska Institutet, 1995-1999
- Research Assistant, Czech Academy of Sciences, 1992-1994
Examina och utbildning
- Docent, Epidemiologi, Karolinska Institutet, 2005
- MEDICINE DOKTORSEXAMEN, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 1999
Uppdrag
- Member, Cancerföreningen, 2024-
- Member of the Faculty Board, Karolinska Institutet, 2020-2022
- Co-director Cancer Research KI., Cancer Research KI is an organization serving as an overarching umbrella organization for cancer research at KI conducted by some 300 research groups., Karolinska Institutet, 2019-2022
- Prefekt, Acting head of department (Sept 2017-Dec 2018), Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, 2017-2018
- Co-director, StratCan, Karolinska Institutet, 2016-2022
- Deputy chair at MEB, with overall responsibility for doctoral studies and junior faculty, Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, 2009-2017
- Deputy Director of CRisP Center at KI, with the overarching aim of Individualized prediction and prevention of breast- and prostate cancer., CRisP Center, Karolinska Institutet, 2008-2020
- Programdirektor, Director of postgraduate studies, Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, 2007-2010
Priser och utmärkelser
- Member of the Nobel Assembly, Karolinska Institutet, 2021
- Young Investigator Award, 6 year full research position from Swedish Cancer Society., Swedish Cancer Society, 2007
Handledning
Handledning till doktorsexamen
- Letizia Orsini, 2026
- Jonas Gjesvik, 2025-
- Paula Camargo Romera, 2024-
- Evripidis Kapanidis, 2023-
- Roxanna Hellgren, Beyond mammography: an evaluation of complementary modalities in breast imaging, 2023
- Johanna Holm, Aggressive breast cancer: epidemiological studies addressing disease heterogeneity, 2023
- Roxanna Hellgren, Beyond mammography: an evaluation of complementary modalities in breast imaging, 2023
- Erwei Zeng, Adjuvant hormone therapy in breast cancer patients : a special focus on treatment discontinuation, 2023
- Xinhe Mao, Epidemiological studies on breast cancer risk factors and screening, 2023
- Ziyan Ma, 2022-
- Rickard Strandberg, Breast cancer natural history models and risk prediction in mammography screening cohorts, 2022
- Mattias Hammarström, Investigating the outcome of low and standard dose tamoxifen in healthy women, 2021-
- Mikael Eriksson, Risk assessment and prevention of breast cancer, 2021
- Shadi Azam, Determinants and influence of mammographic features on breast cancer risk, 2020
- Emilio Ugalde Morales, Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness, 2020
- Gabriel Isheden, Statistical models of breast cancer tumour growth and spread., 2019
- Haomin Yang, Panorama of diseases associated with breast cancer, 2018
- Linda Abrahamsson, Statistical models of breast cancer tumour progression for mammography screening data, 2018
- Ruoqing Chen, The impact of parental cancer on children’s well-being– Nationwide observational studies in Sweden, 2017
- Benedicte Delcoigne, Efficient design and analysis of extended case-control studies, 2017
- Fredrik Strand, Determinants of interval cancer and tumor size among breast cancer screening participants, 2016
- Myeongjee Lee, Effects of kinship and timing on family cancer risk, 2015
- Edoardo Colzani, Health outcomes of women with breast cancer, 2014
- Hatef Darabi, Genetic association and risk prediction of breast cancer from an epidemiological and biostatistical perspective, 2012
- Maria Sandberg (Schelin), Contralateral Breast Cancer - Risk and Prognosis, 2012
- Louise Eriksson, Mammographic density and breast cancer phenotypes, 2012
- Nils Schoof, 2011
- Jingmei Li, Genetic determinants of breast cancer risk, 2011
- Chantal Mascarenhas (Orgéas), Endogenous and exogenous hormonal factors in female cancers – studies of risk and prognosis, 2009
- Linda Lindström, Familial studies on common cancers – a population based approach, 2008
- Monica Leu, Truncation and missing familial links in population-based registers, 2008
- Mikael Hartman, Risk and prognosis of breast cancer among women at high risk of the disease, 2007
- Michaela Prochazka, The risk of second primary lung carcinoma in breast cancer patients, 2006
Handledning av postdoktorala forskare
- Damien Kaukonen, 2022-
- Yuqi Zhang, 2022-
- Qingyang Xiao, 2021-2024
- Qiaoli Wang, 2020-2021
- Juan Rodriguez, 2020-
- Zahra Golabkesh, 2020-2022
- Pui San Tan, 2018-2019
- Felix Grassmann, 2018-2020
- Natalie Holowko, 2016-2021
- Wei He, 2013-2019
- Judith Brand, 2012-2016
- Daniel Klevebring, 2010-2011
- Julia Sandberg, 2010-2011
- Cornelis Biesheuvel, 2009-2010
- Ulf Hannelius, 2009-2012
Uppdrag i kommitté
- Medlem, Swedish Cancer Society, Swedish Cancer Society, 2018-2024
- Medlem, SweTRIBE, Karolinska Institutet, 2017-
- Medlem, BRECT (Breast Cancer Theme Center), Karolinska Institutet, 2014-
- Medlem, Breast Cancer Association Consortium (BCAC), University of Cambridge, 2007-
Gästforskning och resestipendier
- Postdoc, Karolinska Institutet, 2003-2004
- Postdoc, Karolinska Institutet, 2000-2002
Redaktör för vetenskaplig tidskrift
- British Journal of Cancer, Vetenskaplig redaktör, 2019-2021
Expert
- Granskare av forskningsansökningar i nationell konkurrens, Scientific Council for Medicine and Health, Panel for Cancer, Swedish Research Council, 2024
- Sakkunning vid internationella utvärderingar, Reviewer for the Swiss Cancer Research Foundation, Swiss Cancer League, Swiss Cancer League, 2021-2021
- Granskare av forskningsansökningar i nationell konkurrens, Member of the Expert Council, Swedish Cancer Society, 2018-2023
- Sakkunning vid internationella utvärderingar, Panel member and external reviewer, programme on High-Quality and Reliable Diagnostic, Treatment and Rehabilitation, The Research Council of Norway, 2017-2017
- Annat bedömningsuppdrag, Evaluator for numerous grants and positions at KI, Karolinska Institutet, 2016-2023
- Granskare av forskningsansökningar i nationell konkurrens, Reviewer for the Scientific Council for Medicine and Health, Panel for Public Health, Swedish Research Council, 2013-2013
- Sakkunning vid internationella utvärderingar, Member of the External Advisory Board and external reviewer, Breakthrough Generation Study, 2013-2015
- Sakkunnig vid forskningsansökningar, Expert evaluator for the European Commission, evaluation of scientific applications, European Commission, 2010-2010
- Sakkunnig vid forskningsansökningar, Expert evaluator for the European Commission, evaluation of scientific applications, European Commission, 2007-2007